Efficacy and safety of controlled-release versus immediate-release oxycodone: randomized, double-blind evaluation in patients with chronic back pain.

@article{Hale1999EfficacyAS,
  title={Efficacy and safety of controlled-release versus immediate-release oxycodone: randomized, double-blind evaluation in patients with chronic back pain.},
  author={Martin E Hale and R. H. Fleischmann and Richard Salzman and Jan Wild and Tad Iwan and Ruth E Swanton and R F Kaiko and Peter G. Lacouture},
  journal={The Clinical journal of pain},
  year={1999},
  volume={15 3},
  pages={179-83}
}
OBJECTIVE To compare the efficacy and safety of controlled-release oxycodone given every 12 hours with immediate-release oxycodone given four times daily in patients with persistent back pain. DESIGN Randomized, double-blind, active-controlled, two-period crossover trial. PATIENTS Fifty-seven adult outpatients with stable, chronic, moderate-to-severe low back pain despite analgesic therapy were enrolled; 47 were randomized; 11 discontinued for side effects, most commonly nausea and vomiting… CONTINUE READING
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