Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: A randomized trial and individual patient data meta-analysis.

@article{Staykov2017EfficacyAS,
  title={Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: A randomized trial and individual patient data meta-analysis.},
  author={Dimitre Staykov and Joji B. Kuramatsu and Juergen Bardutzky and Bastian Volbers and Stefan T. Gerner and S Kloska and Arnd Doerfler and Stefan Schwab and Hagen Bernhard Huttner},
  journal={Annals of neurology},
  year={2017},
  volume={81 1},
  pages={93-103}
}
OBJECTIVE Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral hemorrhage (ICH) and is associated with permanent shunt dependency in a substantial proportion of patients post-ICH. IVH treatment by intraventricular fibrinolysis (IVF) was recently linked to reduced mortality rates in the CLEAR III study and IVF represents a safe and effective strategy to hasten clot resolution that may reduce shunt rates. Additionally, promising results from observational studies… CONTINUE READING
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