Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study.

  title={Efficacy and safety of belimumab in primary Sj{\"o}gren's syndrome: results of the BELISS open-label phase II study.},
  author={Xavier Mariette and Rapha{\'e}le Seror and Luca Quartuccio and Gabriel Baron and Sara Salvin and Martina Fabris and Fr{\'e}d{\'e}ric Desmoulins and Ga{\'e}tane Nocturne and Philippe Ravaud and Salvatore de Vita},
  journal={Annals of the rheumatic diseases},
  volume={74 3},
BACKGROUND Increased expression of B cell activating factor (BAFF or B lymphocyte stimulator) may explain the B cell activation characteristic of primary Sjögren's syndrome (pSS). OBJECTIVES To evaluate the efficacy and safety of belimumab, targeting BAFF, in patients with pSS. METHODS Patients were included in this bi-centric prospective 1-year open-label trial if they fulfilled American European Consensus group criteria, were anti-Sjögren's syndrome A-positive and had current systemic… CONTINUE READING
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