Efficacy and safety of aerosolized tobramycin in cystic fibrosis

  title={Efficacy and safety of aerosolized tobramycin in cystic fibrosis},
  author={V. Pai and M. Nahata},
  journal={Pediatric Pulmonology},
  • V. Pai, M. Nahata
  • Published 2001
  • Medicine
  • Pediatric Pulmonology
  • Aerosolized tobramycin has been extensively used in cystic fibrosis (CF) patients in order to directly deliver the antibiotic to the endobronchial site of infection, and decrease toxicity by limiting systemic absorption. Aerosolized tobramycin doses ranging from 80 mg twice or three times daily to 600 mg three times daily have been used in various clinical trials. At an 80‐mg dose, preservation of pulmonary function with little or no improvement over the baseline was reported. Tobramycin… CONTINUE READING
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