Efficacy and safety of add-on levetiracetam in refractory childhood epilepsy

  title={Efficacy and safety of add-on levetiracetam in refractory childhood epilepsy},
  author={Hideaki Kanemura and Fumikazu Sano and Tomoko Tando and Kanji Sugita and Masao Aihara},
  journal={Brain and Development},
PURPOSE The purpose of the present study was to evaluate the efficacy and safety of levetiracetam (LEV) in refractory epileptic children. METHODS The study group included 61 outpatients (7 generalized, 48 localization-related, 3 undetermined, 3 unclassified) aged between 16 months and 18 years. LEV was given twice daily at a total dose of 10 mg/kg/day. The final mean dose was 50.7 mg/kg/day. The mean number of prior anti-epileptic drugs was 5.2. The entire treatment period was more than 6… CONTINUE READING

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