Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6

@article{Lawitz2019EfficacyAS,
  title={Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6},
  author={Eric Lawitz and Edward Gane and Jordan J. Feld and Mar{\'i}a Buti and Graham R Foster and Mordechai Rabinovitz and Eduard Z. Burnevich and Helena Katchman and Krzysztof Tomasiewicz and Frederick C. Lahser and Beth Jackson and Melissa Shaughnessy and Stephanie Olsen Klopfer and Wendy W. Yeh and Michael N Robertson and George J Hanna and Eliav Barr and Heather L. Platt and Stuart C. Gordon and Eric Lawitz and Peter Ruane and Amandeep K. Sahota and Norah A. Terrault and Naoky C. Tsai and Sumodh C. Kalathil and Gautham Reddy and Wayne Ghesquiere and Sergio M. Borgia and Brian Conway and Jordan J. Feld and Keith Tsoi and Curtis L. Cooper and Peter Ghali and Alexander James Venn Thompson and Jos{\'e} Luis Calleja Panero and Sabela Lens Maria Buti Ferret and Luis Margusino Franinan and Maria Angeles Castro Iglesias and Ashley Brown and Kaushik Agarwal and Graham Foster and Matthew E. Cramp and Eli Zuckerman and E Veitsman and Michal Cohen and Y. E. Lurie and Ziv Ben Ari and Ewa Janczewska and Aleksandra Szymczak and Waldemar Halota and Robert Flisiak and Adam Mahomed and Mark W. Sonderup and Zelda Erika Punt and Mpho Klaas Kgomo and David C Bernhardi and Eduard Z. Burnevich and Svetlana N. Kizhlo},
  journal={Journal of Viral Hepatitis},
  year={2019},
  volume={26},
  pages={1127 - 1138}
}
Ruzasvir (MK‐8408, an NS5A inhibitor) and uprifosbuvir (MK‐3682, a nonstructural protein 5B nucleotide inhibitor) are highly potent direct‐acting antiviral agents for the treatment of hepatitis C virus (HCV) infection. A phase III clinical trial evaluating the two‐drug combination of ruzasvir 60 mg plus  uprifosbuvir 450 mg suggested suboptimal efficacy in certain HCV genotypes (C‐BREEZE 1; NCT02759315). The aim of the present study was to evaluate the efficacy and safety of ruzasvir in… Expand
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Paper Mentions

Interventional Clinical Trial
This is a nonrandomized, multi-site, open-label trial to evaluate a novel two-drug combination regimen (uprifosbuvir [MK-3682] 450 mg + ruzasvir [RZR; MK-8408] 180 mg once daily… Expand
ConditionsHepatitis C
InterventionDrug
Interventional Clinical Trial
This study is an open-label, multi-center trial to evaluate the novel 2-drug regimen of uprifosbuvir (MK-3682) 450 mg and ruzasvir (MK-8408) 60 mg in participants with chronic… Expand
ConditionsHepatitis C, Chronic
InterventionDrug
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FN performed the literature review and wrote the manuscript; STZ coauthored, edited, and reviewed the manuscript.

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