Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6

@article{Lawitz2019EfficacyAS,
  title={Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6},
  author={Eric Lawitz and Edward J Gane and Jordan J. Feld and Mar{\'i}a Buti and Graham R Foster and Mordechai Rabinovitz and Eduard Z. Burnevich and Helena Katchman and Krzysztof Tomasiewicz and Frederick C. Lahser and Beth Jackson and Melissa Shaughnessy and Stephanie Olsen Klopfer and Wendy W. Yeh and Michael N Robertson and George J Hanna and Eliav Barr and Heather L. Platt and Stuart C. Gordon and Eric Lawitz and Peter Ruane and Amandeep K. Sahota and Norah A. Terrault and Naoky C. Tsai and Sumodh C. Kalathil and G.Mohan Reddy and Wayne Ghesquiere and Sergio M. Borgia and Brian Conway and Jordan J. Feld and Keith Tsoi and Curtis L. Cooper and Peter Ghali and Alexander J Thompson and Jos{\'e} Luis Calleja Panero and S. Ferret and Luis Margusino Franinan and Maria Angeles Castro Iglesias and Ashley S. Brown and Kaushik Agarwal and Graham Foster and Matthew E. Cramp and Eli Zuckerman and E Veitsman and Michal Becker Cohen and Y. E. Lurie and Ziv Ben Ari and Ewa Janczewska and Aleksandra Szymczak and Waldemar Halota and Robert Flisiak and Adam Mahomed and Mark W. Sonderup and Zelda Erika Punt and Mpho Klaas Kgomo and David C Bernhardi and Eduard Z. Burnevich and Svetlana N. Kizhlo},
  journal={Journal of Viral Hepatitis},
  year={2019},
  volume={26},
  pages={1127 - 1138}
}
Ruzasvir (MK‐8408, an NS5A inhibitor) and uprifosbuvir (MK‐3682, a nonstructural protein 5B nucleotide inhibitor) are highly potent direct‐acting antiviral agents for the treatment of hepatitis C virus (HCV) infection. A phase III clinical trial evaluating the two‐drug combination of ruzasvir 60 mg plus  uprifosbuvir 450 mg suggested suboptimal efficacy in certain HCV genotypes (C‐BREEZE 1; NCT02759315). The aim of the present study was to evaluate the efficacy and safety of ruzasvir in… 
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Eliav Barr and Heather Platt are employees of Merck Sharp & Dohme Corp
    We extend our gratitude to the participants, their families, investigators and site personnel who participated in these studies. The C-BREEZE-2 Study Investigators were as follows
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