Efficacy and safety of a standardised 500 unit dose of Dysport® (Clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous cervical dystonia population: results of a prospective, multicentre, randomised, double-blind, placebo-controlled, parallel group study

@article{Wissel2001EfficacyAS,
  title={Efficacy and safety of a standardised 500 unit dose of Dysport® (Clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous cervical dystonia population: results of a prospective, multicentre, randomised, double-blind, placebo-controlled, parallel group study},
  author={Joerg Wissel and Petr Kaňovsk{\'y} and Ev{\vz}en Rů{\vz}i{\vc}ka and Martin Bares and Hana Hortov{\'a} and Hana Streitov{\'a} and Robert Jech and Jan Roth and Christian Brenneis and J{\"o}rg Rudolf M{\"u}ller and Peter Schnider and Eduard Auff and Alan Richardson and Werner Poewe},
  journal={Journal of Neurology},
  year={2001},
  volume={248},
  pages={1073-1078}
}
Results from a dose-ranging study in a selected group of de novo patients with rotational cervical dystonia (CD) suggest that 500 units of Dysport (Clostridium botulinum toxin type A haemaglutinin complex) is the optimal starting dose. The present study aimed to confirm the efficacy and safety profile of this dose in a population of CD patients more representative of those seen in a typical dystonia clinic. A total of 68 patients with moderate to severe CD (Tsui score ≥ 9) were randomly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Botulinum Toxin A (Dysport®)

View 20 Excerpts
Highly Influenced

Cervical Dystonia: From Pathophysiology to Pharmacotherapy

Behavioural neurology • 2013
View 4 Excerpts
Highly Influenced

Botulinum toxin type A in the treatment of patients with cervical dystonia

Biologics : targets & therapy • 2009
View 10 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Benecke R for the German Dystonia

RK Kessler, M Skutta
Study Group • 1999
View 3 Excerpts

What is the optimal dose of botulinum toxin A in the treatment of cervical dystonia ? Results of a double blind , placebo controlled , dose ranging study using Dysport ®

Mark Hallett, W Poewe, +9 authors Künig G – the German Dystonia Study Group
J Neu - rol Neurosurg Psychiatry • 1998

Experience with Botulinum Toxin in Cervical Dystonia

W Poewe, J Wissel
1994

Experience with Botulinum Toxin in Cervical Dystonia. In: Therapy with Botulinum Toxin

W Poewe, J Wissel
1994
View 1 Excerpt

Dystonia--a clinical, neuropathological and therapeutic review.

Journal of neural transmission. Supplementum • 1992
View 2 Excerpts

Similar Papers

Loading similar papers…