Efficacy and safety of a novel ĸ-agonist for managing intractable pruritus in dialysis patients.

@article{Kumagai2012EfficacyAS,
  title={Efficacy and safety of a novel ĸ-agonist for managing intractable pruritus in dialysis patients.},
  author={Hiroo Kumagai and Toshiya Ebata and Kenji Takamori and Katsumasa Miyasato and Taro Muramatsu and Hidetomo Nakamoto and Masanao Kurihara and Tomoji Yanagita and Hiromichi Suzuki},
  journal={American journal of nephrology},
  year={2012},
  volume={36 2},
  pages={175-83}
}
BACKGROUND Our previous placebo-controlled, prospective, double-blind study demonstrated that a new opioid ĸ-receptor agonist, nalfurafine hydrochloride, effectively reduced treatment-resistant pruritus in 337 hemodialysis patients. Thus, we designed this study to evaluate prospectively the efficacy, safety, addiction liability, and pharmacokinetics of nalfurafine given orally for 1 year. METHODS This open-label study examined the effects and adverse drug reactions (ADRs) of 52-week oral… CONTINUE READING
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