Treatment with 5 mg atorvastatin reduced total and LDL - cholesterol by 21 and 27% , respectively , which was similar to 10 mg simvastatin ( total cholesterol -20% , LDL - cholesterol -28% ) and 20 mg pravastatin ( -18 and -24% , respectively ) .
Efficacy and safety of a new cholesterol synthesis inhibitor , atorvastatin , in comparison with simvastatin and pravastatin , in subjects with hypercholesterolemia .
mmol / l were randomly assigned to treatment either with 5 or 20 mg atorvastatin , or with 10 mg simvastatin or 20 mg pravastatin once daily for 4 weeks .
Treatment with 20 mg atorvastatin caused significantly larger reductions in total cholesterol ( -33% ) and LDL - cholesterol ( -44% ) , serum triglycerides ( -23% ) , and apo B ( -40% ) compared to simvastatin and pravastatin .
In a 16-week , multicenter , randomized , open - label cross - over study we compared the efficacy and safety of the new compound atorvastatin for reducing LDL - cholesterol with simvastatin or pravastatin . METHODS .
The effects of this low dose of atorvastatin on triglyceride levels ( -16% ) was not different from that of simvastatin and pravastatin (-8 and -11% , respectively ) .