Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus.

@article{AbdulGhani2012EfficacyAS,
  title={Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus.},
  author={Muhammad Abdul-Ghani and Luke Norton and Ralph A DeFronzo},
  journal={Current diabetes reports},
  year={2012},
  volume={12 3},
  pages={230-8}
}
In addition to its central role in the development of microvascular complications, hyperglycemia plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) by means of glucotoxicity. Thus, effective glycemic control not only reduces the incidence of microvascular complications but also corrects the metabolic abnormalities that contribute to the progression of the disease. Progressive β-cell failure and multiple side effects, including hypoglycemia and weight gain, associated… CONTINUE READING

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