Efficacy and safety of Re-Du-Ning injection in the treatment of seasonal influenza: results from a randomized, double-blinded, multicenter, oseltamivir-controlled trial

Abstract

OBJECTIVE To assess the efficacy and safety of RDNI in the treatment of seasonal influenza. RESULTS 1575 participants were screened and 229 completed the study and had a RT-PCR laboratory confirmation of influenza virus infection. Fever alleviation time was 2 and 6 hours, and fever clearance time was 27 and 47 in RDNI and oseltamivir, with significant difference between two groups. Total scores of influenza symptoms descended more in RDNI than oseltamivir on day 2 and day 3. Single symptom such as fever, aversion to cold, sore throat and nasal obstruction score descended more in RDNI than oseltamivir on different days. 20 subjects used aspirin during the trial, and there was no significant difference between two groups. MATERIALS AND METHODS We conducted a randomized, double-blind, double-dummy, oseltamivir controlled clinical trial. Patients with a positive influenza rapid test diagnosis were enrolled and randomized to receive RDNI or oseltamivir. Primary outcome was the median fever alleviation and clearance time. Secondary outcomes were total 8 influenza symptom scores, the single influenza symptom score, and the frequency of aspirin usage. CONCLUSIONS The effect of RDNI was not worse than oseltamivir on the alleviation of influenza symptoms. RDNI was well tolerated, with no serious adverse events noted during the study period.

DOI: 10.18632/oncotarget.19220

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Cite this paper

@inproceedings{Liu2017EfficacyAS, title={Efficacy and safety of Re-Du-Ning injection in the treatment of seasonal influenza: results from a randomized, double-blinded, multicenter, oseltamivir-controlled trial}, author={Ying X. Liu and Wei Mu and Wei Xiao and Bao-Lin Wei and Lan Wang and Xin-qiao Liu and Xu-dong Xiong and Xiaoming Huang and Ye-qing Zhang and Haiming Chen and Feng-Jie Yan and Yu-Ping Tan and Yu-hong Huang}, booktitle={Oncotarget}, year={2017} }