Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

@article{Kopke2015EfficacyAS,
  title={Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial},
  author={Richard D. Kopke and Martin D Slade and Ronald L. Jackson and Tanisha L. Hammill and Stephen A. Fausti and Brenda L. Lonsbury-Martin and Alicia R. Sanderson and Laura Dreisbach and Peter M. Rabinowitz and Peter Torre and Ben J. Balough},
  journal={Hearing Research},
  year={2015},
  volume={323},
  pages={40-50}
}
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61 Citations
Highly Influential Citations
4
Background Citations
20
Methods Citations
5
Results Citations
1

61 Citations

Strategies for Evaluating Antioxidant Efficacy in Clinical Trials Assessing Prevention of Noise-Induced Hearing Loss
TLDR
This chapter provides a review of the test measures that are commonly used, as well as other emerging metrics that may have utility in the future, and reviews current and completed clinical trials.
Effect of N-acetyl-cysteine in Prevention of Noise-Induced Hearing Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TLDR
The present review and meta-analysis recommends that N-acetyl-cysteine may be considered as an option for protective therapy for noise-induced hearing loss, and larger randomized controlled trials are requisite for further investigation and verification.
Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design
TLDR
This review revealed little consistency in the noise-exposed populations in which drugs are evaluated or the primary outcomes used to measure NIHL prevention, and multiple criteria are available for monitoring NIHL, but the specific criterion to be used to define clinically significant otoprotection remains a topic of discussion.
Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: A meta-analysis
N-acetylcysteine Treatment Reduces Noise-induced Hearing Loss in Guinea Pig
TLDR
The results suggest that antioxidants could be a pharmacological target for noise-induced hearing loss and that NAC can be used as a positive reference compound for new drug efficacy studies targeting hearing disorders.
The Effect of Atorvastatin on Preventing Noise-Induced Hearing Loss: An Experimental Study
TLDR
Low dose atorvastatin (5 mg/kg) used before exposure to noise can probably prevent NIHL in rats and this effect was not observed with higher doses of the drug.
Emerging therapeutic interventions against noise-induced hearing loss
TLDR
This review outlines the pathology and pathophysiology of hearing loss as seen in humans and animal models and suggests that existing results combined with the search for efficacious new therapies should establish a viable treatment within a decade.
Otoprotectants: From Research to Clinical Application.
TLDR
There is an urgent need for otoprotective drug agents for the purpose of protecting the inner ear against damage, and preventing associated hearing loss (otoprotection).
N-acetylcysteine as a single therapy for sudden deafness
TLDR
Like NAC ameliorates hearing loss from acoustic trauma in the inner ear, N-acetyl-L-cysteine may also rescue hearing lossFrom sudden deafness confined to the innerEar.
Pharmacological Prevention of Noise-induced Hearing Loss: A Systematic Review
TLDR
While several heterogenous articles demonstrated promising results for Mg-aspartate, carbogen, vitamin B12, and alpha-lipoic acid, the clinical significance of these pharmaceuticals remains unclear.
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References

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Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music.
TLDR
The antioxidant N-acetylcysteine was evaluated to determine if it would reduce temporary changes in auditory function as a result of exposure to loud music in humans, and no statistically significant differences were found.
The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: a controlled trial.
TLDR
The most striking finding was that the non-linearity of the cochlea, that was strongly reduced in the group without NAC, was practically unchanged in the NAC-group throughout the study, which supports use of NAC treatment.
Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine
Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss.
TLDR
It is suggested that SAL in combination with NAC is effective in reducing noise damage to the cochlea, but SAL has a relatively narrow therapeutic dosing window.
Prevention of impulse noise-induced hearing loss with antioxidants
Conclusion These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant…
Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs.
TLDR
The data suggest that N-acetylcysteine is able to attenuate the toxic effect of acoustic trauma and could represent an interesting molecule for preventing inner ear injuries.
Dose and time-dependent protection of the antioxidant N-l-acetylcysteine against impulse noise trauma
Different strategies in treating noiseinduced hearing loss with N-acetylcysteine.
TLDR
The role played by the timing of NAC injection was important for the OHC protection index and the best protection scheme was observed in the group receiving NAC after noise exposure, but full recovery of cochlear function was not observed in any of the tested groups.
N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers
Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers.
TLDR
It is shown that NAC and ginseng can reduce noise induced TTS in workers exposed to occupational noise and further studies are needed to prove antioxidants benefits in hearing conservation programs.
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