Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

@article{Kopke2015EfficacyAS,
  title={Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial},
  author={Richard D. Kopke and Martin D Slade and Ronald L. Jackson and Tanisha L. Hammill and Stephen A. Fausti and Brenda L. Lonsbury-Martin and Alicia R. Sanderson and Laura Dreisbach and Peter M. Rabinowitz and Peter Torre and Ben J. Balough},
  journal={Hearing Research},
  year={2015},
  volume={323},
  pages={40-50}
}
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Otoprotectants: From Research to Clinical Application.
TLDR
There is an urgent need for otoprotective drug agents for the purpose of protecting the inner ear against damage, and preventing associated hearing loss (otoprotection).
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TLDR
Like NAC ameliorates hearing loss from acoustic trauma in the inner ear, N-acetyl-L-cysteine may also rescue hearing lossFrom sudden deafness confined to the innerEar.
Pharmacological Prevention of Noise-induced Hearing Loss: A Systematic Review
TLDR
While several heterogenous articles demonstrated promising results for Mg-aspartate, carbogen, vitamin B12, and alpha-lipoic acid, the clinical significance of these pharmaceuticals remains unclear.
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References

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Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music.
TLDR
The antioxidant N-acetylcysteine was evaluated to determine if it would reduce temporary changes in auditory function as a result of exposure to loud music in humans, and no statistically significant differences were found.
The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: a controlled trial.
TLDR
The most striking finding was that the non-linearity of the cochlea, that was strongly reduced in the group without NAC, was practically unchanged in the NAC-group throughout the study, which supports use of NAC treatment.
Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss.
TLDR
It is suggested that SAL in combination with NAC is effective in reducing noise damage to the cochlea, but SAL has a relatively narrow therapeutic dosing window.
Prevention of impulse noise-induced hearing loss with antioxidants
Conclusion These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant
Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs.
TLDR
The data suggest that N-acetylcysteine is able to attenuate the toxic effect of acoustic trauma and could represent an interesting molecule for preventing inner ear injuries.
Different strategies in treating noiseinduced hearing loss with N-acetylcysteine.
TLDR
The role played by the timing of NAC injection was important for the OHC protection index and the best protection scheme was observed in the group receiving NAC after noise exposure, but full recovery of cochlear function was not observed in any of the tested groups.
Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers.
TLDR
It is shown that NAC and ginseng can reduce noise induced TTS in workers exposed to occupational noise and further studies are needed to prove antioxidants benefits in hearing conservation programs.
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