Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.

@article{Fulcher2015EfficacyAS,
  title={Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.},
  author={Jordan R Fulcher and Rachel L. O'Connell and Merryn Voysey and Jonathan Emberson and Lisa Blackwell and Borislava Mihaylova and John Simes and Rory Collins and Adrienne Kirby and Helen Colhoun and Eugene Braunwald and John La Rosa and Terje Rolf Pedersen and Andrew Tonkin and Barry C. Davis and Peter J. Sleight and Maria Grazia Franzosi and Colin N. Baigent and Anthony Keech},
  journal={Lancet},
  year={2015},
  volume={385 9976},
  pages={1397-405}
}
BACKGROUND Whether statin therapy is as effective in women as in men is debated, especially for primary prevention. We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database to compare the effects of statin therapy between women and men. METHODS We performed meta-analyses on data from 22 trials of statin therapy versus control (n=134,537) and five trials of more-intensive versus less-intensive statin therapy (n=39,612). Effects on major… CONTINUE READING
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