Efficacy and safety of 12 weeks of osteoarthritic pain therapy with once-daily tramadol (Tramadol Contramid OAD).

@article{Fishman2007EfficacyAS,
  title={Efficacy and safety of 12 weeks of osteoarthritic pain therapy with once-daily tramadol (Tramadol Contramid OAD).},
  author={Ritchard L Fishman and Charles James Kistler and Michael T Ellerbusch and Raul Tomas Aparicio and Sharad S Swami and Mark E Shirley and Adesh K Jain and Louise Fortier and Sybil Robertson and Sylvie Bouchard},
  journal={Journal of opioid management},
  year={2007},
  volume={3 5},
  pages={273-80}
}
This placebo-controlled study examined the analgesic efficacy, safety, and clinical benefit of Tramadol Contramid OAD, a once-daily formulation with both immediate- and extended-release components. Five hundred and fifty-two patients with moderate to severe pain due to osteoarthritis (OA) of the knee were randomized into this multicenter, double-blind, parallel arm study. After randomization to Tramadol Contramid OAD 100, 200, or 300 mg, or to placebo, patients' dose was titrated to the fixed… CONTINUE READING

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