Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria.

@article{Denis2002EfficacyAS,
  title={Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria.},
  author={Mey Bouth Denis and Timothy M E Davis and Sean Hewitt and Sandra Incardona and Khim Nimol and Thierry Fandeur and Yi Poravuth and Chiv Lim and Doung 7 Socheat},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2002},
  volume={35 12},
  pages={1469-76}
}
The safety and efficacy of a novel combination of dihydroartemisinin (DHA) and piperaquine, Artekin (Holleykin Pharmaceuticals), were assessed in 106 patients (76 children and 30 adults) with uncomplicated falciparum malaria from 2 remote areas in Cambodia. Age-based doses were given at 0, 8, 24, and 32 h. Mean total DHA and piperaquine doses were 9.1 and 73.9 mg/kg, respectively, for children and 6.6 and 52.9 mg/kg for adults. All patients became aparasitemic within 72 h. Excluding the results… CONTINUE READING

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