Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrug-resistant Plasmodium falciparum malaria.

@article{Sabchareon1998EfficacyAP,
  title={Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrug-resistant Plasmodium falciparum malaria.},
  author={Arunee Sabchareon and Phanorsri Attanath and P Phanuaksook and Pornthep Chanthavanich and Y Poonpanich and D Mookmanee and Tan Chongsuphajaisiddhi and Brian M. Sadler and Ziad Hussein and Craig J Canfield and D. Bruce Hutchinson},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={1998},
  volume={92 2},
  pages={201-6}
}
A trial was conducted in 32 Thai children with uncomplicated multidrug-resistant falciparum malaria to assess the efficacy, safety and pharmacokinetics of atovaquone and proguanil; plasma concentrations of atovaquone, proguanil and its metabolite, cycloguanil, were measured in a subset of 9 children. The children received atovaquone (17 mg/kg/d for 3 d) plus proguanil (7 mg/kg/d for 3 d). Twenty-six children who had only Plasmodium falciparum infection and remained in hospital for 28 d were… CONTINUE READING