Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis.

@article{Watts2007EfficacyAD,
  title={Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis.},
  author={Douglas M. Watts and Robert B. Tesh and Marina Siirin and Amelia Travassos da Rosa and Patrick C. Newman and David Clements and Steven A. Ogata and Beth-Ann Griswold Coller and Carolyn Weeks-Levy and Michael M. Lieberman},
  journal={Vaccine},
  year={2007},
  volume={25 15},
  pages={
          2913-8
        }
}
The efficacy of a new recombinant subunit West Nile virus (WNV) vaccine candidate was determined in a hamster model of meningoencephalitis. Groups of hamsters were immunized subcutaneously with a WNV recombinant envelope protein (80E) with or without WNV non-structural protein 1 (NS1) mixed with adjuvant or adjuvant alone. At 2 weeks, 6 months, and 12 months after two immunizations at 4 week intervals with the respective immunogens, groups of animals were challenged via the intraperitoneal… CONTINUE READING
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