Efficacy and cost of HMG-CoA reductase inhibitors in the treatment of patients with primary hyperlipidemia.

@article{Perreault2000EfficacyAC,
  title={Efficacy and cost of HMG-CoA reductase inhibitors in the treatment of patients with primary hyperlipidemia.},
  author={S{\'e}bastien Perreault and Carey M Levinton and Jacques Le Lorier},
  journal={The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique},
  year={2000},
  volume={7 3},
  pages={144-54}
}
BACKGROUND Screening for hyperlipidemia is a substantial cost burden, as is its treatment. The choice of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and the dose level may have significant implications for both efficient and cost effective therapy. OBJECTIVE To compare the efficiency and cost of statins. MATERIALS AND METHODS A meta-analysis was conducted of randomized, controlled trials of monotherapy with fixed doses of statins published in the literature until… CONTINUE READING

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The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
The percentage reduction ( 95% confidence intervals ) of low density lipoprotein ( LDL ) cholesterol levels was calculated using a random - effects model .
By targeting a reduction between 25% and 29% , significantly higher cost efficiencies were found with simvastatin 5 mg ( -28.9%/dollar ) , cerivastatin 0.2 mg ( -23.8%/dollar ) and fluvastatin 40 mg ( -23.3%/dollar ) .
By targeting a reduction between 25% and 29% , significantly higher cost efficiencies were found with simvastatin 5 mg ( -28.9%/dollar ) , cerivastatin 0.2 mg ( -23.8%/dollar ) and fluvastatin 40 mg ( -23.3%/dollar ) .
For reductions in LDL cholesterol concentrations of 30% to 34% , statistically higher cost efficiencies were achieved with simvastatin 20 mg ( -15.0%/dollar ) and pravastatin 40 mg ( -14 .
For reductions in LDL cholesterol concentrations of 30% to 34% , statistically higher cost efficiencies were achieved with simvastatin 20 mg ( -15.0%/dollar ) and pravastatin 40 mg ( -14 .
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