Efficacy and adverse events of oral isotretinoin for acne: a systematic review

@article{Vallerand2018EfficacyAA,
  title={Efficacy and adverse events of oral isotretinoin for acne: a systematic review},
  author={I. Vallerand and R. Lewinson and M. Farris and C. Sibley and M. Ramien and A. Bulloch and S. Patten},
  journal={British Journal of Dermatology},
  year={2018},
  volume={178}
}
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in patients with acne is lacking. We searched MEDLINE, Embase, Cochrane Central, relevant web pages and bibliographies for randomized controlled trials in acne evaluating isotretinoin vs. control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total 760 patients randomized), containing mostly men. Mean treatment ages ranged… Expand
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