Efficacy and adverse events of oral isotretinoin for acne: a systematic review

@article{Vallerand2018EfficacyAA,
  title={Efficacy and adverse events of oral isotretinoin for acne: a systematic review},
  author={I A Vallerand and Ryan T. Lewinson and Megan S. Farris and Christopher D. Sibley and Michele L. Ramien and Andrew G. M. Bulloch and Scott B. Patten},
  journal={British Journal of Dermatology},
  year={2018},
  volume={178}
}
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in patients with acne is lacking. We searched MEDLINE, Embase, Cochrane Central, relevant web pages and bibliographies for randomized controlled trials in acne evaluating isotretinoin vs. control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total 760 patients randomized), containing mostly men. Mean treatment ages ranged… 

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References

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Isotretinoin does not appear to be associated with the development of depression, and denying patients with significant acne an effective medication for fear of developing depression may not be indicated at this point in time.

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Isotretinoin exposure is not associated with an increased risk of developing both ulcerative colitis and Crohn’s disease.

Clinical and microbiological comparisons of isotretinoin vs. tetracycline in acne vulgaris.

Antibiotic treatment was found to be a good alternative to isot retinoin, regardless of the presence of antibiotic-resistant P. acnes, although isotretinoin had a better effect, with prolonged remission after treatment.

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Isotretinoin versus weekly pulse dose azithromycin in the treatment of acne-a comparative study

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Hemodialysis-Related Nodulocystic Acne Treated with Isotretinoin

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Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne.

The combination of topical 20% AA cream and oral minocycline is an highly effective treatment in severe forms of acne and can be regarded as a valuable alternative in patients for whom isot retinoin is not indicated, who do not wish to use or can not tolerate isotretinoin therapy and particularly in female acne patients of child-bearing potential.

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The most common adverse events, observed during treatment, are mucocutaneous and ophthalmological and laboratory abnormalities and effects in the nervous, musculoskeletal, gastrointestinal, pulmonary and other systems have been described.
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