Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia — a retrospective study of 387 patients

@article{Naber1989EfficacyAA,
  title={Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia — a retrospective study of 387 patients},
  author={Dieter Naber and M. Leppig and Renate Grohmann and Hanns Hippius},
  journal={Psychopharmacology},
  year={1989},
  volume={99},
  pages={S73-S76}
}
Medical charts of 387 in-patients (schizophrenia n=284, tardive dyskinesia, TD, n=48), were analyzed to evaluate efficacy and adverse effects of clozapine. These patients were previously treated with between two and four other neuroleptics and were either therapy resistant or had severe side effects. Schizophrenic patients were treated with clozapine for 48±35 (TD 49±40) days, dosage was 189±119 (TD 220±176) mg. Four per cent showed worsening, 13% no change, 38% slight improvement, 42% marked… CONTINUE READING
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