Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer

@article{Rao1988EfficacyAA,
  title={Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer},
  author={B. Ramanath Rao and Albert A. Geldof and Clasina L. van der Wilt and Herman J. de Voogt},
  journal={The Prostate},
  year={1988},
  volume={13}
}
Treatment effects of RU 23908 antiandrogen (Anandron®) and estrogen in low doses on hormone‐dependent rat prostatic adenocarcinoma (R3327‐H) were investigated. Tumorbearing Copenhagen rats were treated for 6 weeks with 8 μg Anandron and 1 μg estradiol‐17β every two days. Reduction and counteraction of androgen synthesis and action was established by an observed decline in serum testosterone level and by changes in both histology and weight of androgen target organs. Prostate tumor growth rate… 
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6 Citations

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Endocrine mechanisms of suppressive effect of low dose estrogen-antiandrogen treatment on androgen-dependent organs of male rats
TLDR
Hex administration in low doses, in combination with Fl, could be an alternative method for a complete androgen blockade of the accessory sexual glands in mature intact male rats.
Effect of a nonsteroidal antiandrogen, anandron, on the reproductive system and fertility in male rats.
TLDR
The results suggest that the peripheral antiandrogenic potency of Anandron in intact animals is insufficient to completely neutralize the elevated levels of androgens.
Evaluation of Win 49,596, a novel steroidal androgen receptor antagonist, in animal models of prostate cancer
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A series of experiments were conducted to evaluate the effects of Win 49,596, a novel steroidal androgen receptor antagonist, in animal models of prostate cancer, and decreased the weight of the prostate in tumor‐bearing animals.
Chapter 21. New Horizons in the Treatment of Proliferative Prostatic Disease
TLDR
The discovery and development of potent and selective inhibitors of 5α-reductase and “pure” AR antagonists that do not uncouple negative-feedback at the hypothalamic/pituitary demonstrates continuing interest in this therapeutic arena.
Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. II. Pharmacodynamic Responses
TLDR
The data demonstrate that the E2-CDS effects on gonadotropins suppression are dose and time dependent and this duration of suppression is consistent with the long half-lives of the E1-Q+ metabolites in the brain.
Consideration of the use of 17β-N,N-diethylcarbamoyl-4-methyl-4-aza-5-α-androstan-3-one (4MA), a 5α-reductase inhibitor, in prostate cancer therapy
TLDR
4MA decreased tumour growth rate in a dose-dependent manner, which was reflected in a decreased incorporation of BrdUrd in DNA of glandular epithelial cells in the tumour, which has to be interpreted as not being purely due to 5α-reductase inhibition.

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