Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer

  title={Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer},
  author={B. Ramanath Rao and Albert A. Geldof and Clasina L. van der Wilt and Herman J. de Voogt},
  journal={The Prostate},
Treatment effects of RU 23908 antiandrogen (Anandron®) and estrogen in low doses on hormone‐dependent rat prostatic adenocarcinoma (R3327‐H) were investigated. Tumorbearing Copenhagen rats were treated for 6 weeks with 8 μg Anandron and 1 μg estradiol‐17β every two days. Reduction and counteraction of androgen synthesis and action was established by an observed decline in serum testosterone level and by changes in both histology and weight of androgen target organs. Prostate tumor growth rate… 
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The nonsteroidal antiandrogen RU 23908 (AnandronR) weakly interacts with the prostatic cytosolic androgen receptor and shows a fast dissociation rate. When administered to immature castrated rats up
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Effectiveness of complete versus partial androgen withdrawal therapy for the treatment of prostatic cancer as studied in the Dunning R-3327 system of rat prostatic adenocarcinomas.
It is demonstrated that complete androgen withdrawal consisting of surgical castration in combination with daily treatment with the potent antiandrogen, cyproterone acetate, was no more effective in terms of tumor growth retardation or overall host survival than was partial androgens withdrawal induced by castration alone.