Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis

@article{Moffa2020EfficacyAA,
  title={Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis},
  author={Adriano H. Moffa and Donel M. Martin and Angelo Alonzo and Djamila Bennabi and Daniel M. Blumberger and Isabela Judith Martins Bense{\~n}or and Zafiris J. Daskalakis and Felipe Fregni and Emmanuel Haffen and Sarah H. Lisanby and Frank Padberg and Ulrich Palm and La{\'i}s B. Razza and Bernardo Sampaio-Jr and Colleen K. Loo and Andr{\'e} Russowsky Brunoni},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2020},
  volume={99}
}
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Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data
TLDR
The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care, and the most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.
Transcranial direct current stimulation for major depression: an updated systematic review and meta-analysis.
TLDR
Active tDCS was statistically superior to sham tDCS for the acute depression treatment, although its role as a clinical intervention is still unclear owing to the mixed findings and heterogeneity of the reviewed studies.
Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial
TLDR
Transcranial direct current stimulation was an effective, safe, and tolerable add-on intervention for this small bipolar depression sample and further trials should examine tDCS efficacy in a larger sample.
Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis
TLDR
These findings provide evidence for the consideration of non-surgical brain stimulation techniques as alternative or add-on treatments for adults with major depressive episodes and highlight important research priorities in the specialty of brain stimulation.
Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial
TLDR
Findings confirm earlier reports of the antidepressant efficacy and safety of tDCS and Vigilance for mood switching is advised when administering tDCS to individuals with bipolar disorder.
The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial.
TLDR
In MDD, the combination of tDCS and sertraline increases the efficacy of each treatment, and tDCS only (but not sERTraline only) was superior to placebo/sham tDCS.
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