Efficacy and Toxicity of High-Dose Colistin in Multidrug-Resistant Gram-Negative Bacilli Infections: A Comparative Study of a Matched Series.

Abstract

BACKGROUND Colistimethate sodium (CMS) is the commercialized form of colistin that is effective against multiresistant Gram-negative bacilli. Its main side effects are nephrotoxicity and neurotoxicity. Pharmacodynamic dosages showed that they were infratherapeutic. Therefore, strategies with higher doses were proposed. The aim of this study was to assess… (More)
DOI: 10.1159/000442786

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@article{Trifi2016EfficacyAT, title={Efficacy and Toxicity of High-Dose Colistin in Multidrug-Resistant Gram-Negative Bacilli Infections: A Comparative Study of a Matched Series.}, author={Ahlem Trifi and Sami Abdellatif and Foued Daly and Khaoula Mahjoub and Rochdi Nasri and Mouna Oueslati and Rahma Mannai and M. Fouad Bouzidi and Salah Ben Lakhal}, journal={Chemotherapy}, year={2016}, volume={61 4}, pages={190-6} }