Efficacy and Tolerability of Moclobemide in Comparison with Placebo, Tricyclic Antidepressants, and Selective Serotonin Reuptake Inhibitors in Elderly Depressed Patients: A Clinical Overview

  title={Efficacy and Tolerability of Moclobemide in Comparison with Placebo, Tricyclic Antidepressants, and Selective Serotonin Reuptake Inhibitors in Elderly Depressed Patients: A Clinical Overview},
  author={R. Amrein and Max Stabl and Stephan A. Henauer and Erhard Affolter and I. Jonkanski},
  journal={The Canadian Journal of Psychiatry},
  pages={1043 - 1050}
Objective: To review the efficacy and safety of moclobemide in comparison with TCAs(for our purposes, “TCAs” will represent tricyclic and tetracyclic antidepressants, including maprotilin and mianserin) and selective serotonin reuptake inhibitors (SSRIs) in elderly depressed patients. Methods: The efficacy data reviewed were obtained from the following sources: 1) results of published studies in the elderly; 2) data on patients aged ≥ 60 years extracted from all available controlled trials in… Expand
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A double-blind comparative trial of moclobemide v. imipramine and placebo in major depressive episodes.
Patients suffering from a major depressive episode according to DSM-III criteria were randomly allocated to groups receiving either moclobemide, imipramine, or placebo treatment, and the overall assessment of tolerance clearly favoured placebo and moclOBemide over imipramsine. Expand
Clinical Activity and Tolerability of Trazodone, Mianserin, and Amitriptyline in Elderly Subjects with Major Depression: A Controlled Multicenter Trial
A comparable therapeutic response but a better tolerance for atypical antidepressants, particularly TRA, make advisable the use of the latter drug in the elderly population, and GDS seems to be most reliable in detecting changes in elderly depressive symptomatology. Expand
A Retrospective Chart Review of Antidepressant Use, Effectiveness, and Adverse Effects in Adults Age 70 and Older.
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Many older patients who undergo antidepressant therapy discontinue because of side effects; however patients are likely to improve or recover with sustained therapy. Expand
Effects of Moclobemide on Depressive Symptoms and Cognitive Performance in a Geriatric Population: A Controlled Comparative Study Versus Imipramine
Results indicate that moclobemide could prove to be the drug of choice in geriatric depression, given that cognitive effects are prominent in the aged. Expand
Reversible and selective inhibitors of monoamine oxidase A in the treatment of depressed elderly patients
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Comparative efficacy and safety of MAOIs versus TCAs in treating depression in the elderly
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