Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials

  title={Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials},
  author={Zhi-Qi Fanning Wang and Ambrish Singh and Graeme Jones and Tania M Winzenberg and Changhai Ding and Arvind Chopra and Siddhartha Das and Debashish Danda and Laura L. Laslett and Benny Antony},
  journal={Current Rheumatology Reports},
Purpose of the Review Finding appropriate pharmacological options to treat osteoarthritis (OA) remain challenging. We aimed to determine the efficacy and safety of all types of turmeric extracts for the management of knee OA. Recent Findings Sixteen RCTs of up to 16 weeks duration including 1810 adults with knee OA were included. Eleven RCTs compared the efficacy of turmeric extracts with placebo and five with active comparators (NSAIDs). The overall risk bias of included RCTs was moderate… 
Quality of Evidence Supporting the Role of Curcuma Longa Extract/Curcumin for the Treatment of Osteoarthritis: An Overview of Systematic Reviews
CLE/C may be an effective and safe complementary treatment for OA, however, further standard SRs/MAs and RCTs are needed to provide an evidence-based medical rationale for this.
An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study
The findings support the potential efficacy ofCurcumin for the treatment of osteoarthritis of the knee but studies of longer duration, varying treatment doses, differing curcumin extracts, and the use of other objective outcome measures will be helpful to expand on these findings.
The comparison of curcuminoid formulations or its combination with conventional therapies versus conventional therapies alone for knee osteoarthritis
Curcuminoid formulations were superior to chondroitin sulfate/glucosamine in reducing VAS, total WOMAC score, and WOMac score for stiffness/difficulty in physical function, while no significant difference was seen in reducing WOMAC pain score and Karnofsky Performance Scale score.
Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research
How cartilage tissue engineering materials and BDEs play a role in cartilage repair, as well as the current research status are explained.
Osteoarthritis Progression: Mitigation and Rehabilitation Strategies
This review highlights recent therapeutic advancements in osteoarthritis treatment consisting of pharmacologics, nutraceuticals, biologicics, and exercise while emphasizing the current state of post-arthroplasty rehabilitation.
The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review
This review is an attempt to understand the pathophysiological connections between obesity and arthritis, and describes treatment options derived from medicinal, spice, and aromatic plants.
Considerations to Be Taken When Carrying Out Medicinal Plant Research—What We Learn from an Insight into the IC50 Values, Bioavailability and Clinical Efficacy of Exemplary Anti-Inflammatory Herbal Components
The value of plasma levels as pharmacokinetic surrogates in comparison to the more informative value of tissue concentrations is discussed to avoid inaccurate predictions for the efficacy of herbal components in vivo and to unlock the “black box” of herbal mixtures.


Efficacy and safety of turmeric extracts in knee osteoarthritis: protocol for a systematic review and meta-analysis of randomised controlled trials
A planned systematic review and meta-analysis aims to assess the efficacy and safety of turmeric extracts for the treatment of knee OA.
Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial
The study demonstrates safety and efficacy of NR-INF-02 as a useful treatment option for patients with primary painful knee OA and shows a significant decrease in use of rescue medication and clinical and subjective improvement compared to placebo.
Efficacy and side effect of curcumin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials.
Curcumin can treat OA patients effectively, improving WOMAC score and VAS score, and the side effect of curcumin was not higher than that of ibuprofen.
Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis
Curcuma longa extract was more effective than placebo for knee pain but did not affect knee effusion-synovitis or cartilage composition and Multicenter trials with larger sample sizes are needed to assess the clinical significance.
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
C. domestica extracts are as effective as ibuprofen for the treatment of knee osteoarthritis and two-thirds rated themselves as improved in a global assessment.
Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis.
C. domestica extracts seem to be similarly efficacious and safe as ibuprofen for the treatment of knee OA, and their mean scores at weeks 0, 2, 4, and 6 were significantly improved when compared with the baseline values.
Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study
Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA, and can be an alternative treatment option in the patients with knees OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.
Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double‐Blind Placebo‐Controlled Trial
In patients with mild‐to‐moderate knee OA, curcuminoids represent an effective and safe alternative treatment for OA and there was no considerable adverse effect in both groups.
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA and Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects ofCurcumin and boswelli acid.