Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial

@article{Oreardon2007EfficacyAS,
  title={Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial},
  author={John P O'reardon and Hugh Brent Solvason and Philip G. Janicak and Shirlene M. Sampson and Keith E. Isenberg and Ziad Nahas and William M. McDonald and David H Avery and Paul B. Fitzgerald and Colleen K. Loo and Mark A Demitrack and Mark S. George and Harold A. Sackeim},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={1208-1216}
}

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TLDR
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TLDR
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TLDR
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TLDR
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Partial clinical response to 2 weeks of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression.

TLDR
This study provides the first evidence showing that 2 Hz rTMS over the right parietal cortex may have antidepressant properties, and warrants further research.

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TLDR
These results document that rTMS is feasible, safe and well tolerated under naturalistic conditions and should be added on to continued psychopharmacological treatment in a naturalistic clinical setting.
...

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Evidence is provided for the short-term efficacy of slow repetitive TMS in patients with recurrent major depression as compared with electroconvulsive therapy as well as the long-term outcome of this treatment in major depression and possibly other psychiatric disorders.

Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial.

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Treatment with LFR-TMS may prove to be an appropriate initial repetitive TMS strategy in depression taking into account safety, tolerability, and efficacy considerations.

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Repetitive transcranial magnetic stimulation did not provide significantly greater improvement than did sham treatment and a 4-week course of rTMS, as administered in this study, was safe.

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This meta-analysis suggests that rapid-rate rTMS is no different from sham treatment in major depression; however, the power within these studies to detect a difference was generally low.

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These placebo-controlled results suggest that daily left prefrontal repetitive transcranial magnetic stimulation has antidepressant activity when administered at these parameters.

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Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.

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Transcranial magnetic stimulation (TMS) is a technology that allows for non-invasive modulation of the excitability and function of discrete brain cortical areas. TMS uses alternating magnetic fields