Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial

  title={Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial},
  author={John P O'reardon and Hugh Brent Solvason and Philip G. Janicak and Shirlene M. Sampson and Keith E. Isenberg and Ziad Nahas and William M. McDonald and David H Avery and Paul B. Fitzgerald and Colleen K. Loo and Mark A Demitrack and Mark S. George and Harold A. Sackeim},
  journal={Biological Psychiatry},

Transcranial magnetic stimulation in the acute treatment of major depressive disorder: clinical response in an open-label extension trial.

This open-label study provides further evidence that TMS is a safe and effective treatment of major depressive disorder and provided additional benefit to some patients who failed to respond to 4 weeks of treatment, suggesting that longer courses of treatment may confer additional therapeutic benefit.

Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial

Deep transcranial magnetic stimulation constitutes a novel intervention in MDD, which is efficacious and safe in patients not responding to antidepressant medications, and whose effect remains stable over 3 months of maintenance treatment.

The Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression.

The results of the study showed that TMS treatment is an effective and safe treatment for patients with treatment-resistant bipolar depression.

Left prefrontal transcranial magnetic stimulation for treatment-resistant depression in adolescents: a double-blind, randomized, sham-controlled trial

Although TMS treatment produced a clinically meaningful change in depressive symptom severity, this did not differ from sham treatment, and future studies should focus on strategies to reduce the placebo response and examine the optimal dosing of TMS for adolescents with TRD.

Treatment for Major Depressive Disorder by Repetitive Transcranial Magnetic Stimulation in Different Parameters: A Randomized Double-Blinded Controlled Trial

It is concluded that there were no statistical differences in the efficacy of rTMS between unilateral left and bilateral DLPFC, and between 5 and 10 Hz for treating MDD.

Augmentative repetitive navigated transcranial magnetic stimulation (rTMS) in drug-resistant bipolar depression.

Augmentative low-frequency rTMS of the right DLPFC combined with brain navigation was effective and well tolerated in a small sample of drug-resistant bipolar depressive patients, even though the lack of a sham controlled group limits confidence in the results.

Partial clinical response to 2 weeks of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression.

This study provides the first evidence showing that 2 Hz rTMS over the right parietal cortex may have antidepressant properties, and warrants further research.

Transcranial magnetic stimulation for the treatment of depression: feasibility and results under naturalistic conditions: a retrospective analysis

These results document that rTMS is feasible, safe and well tolerated under naturalistic conditions and should be added on to continued psychopharmacological treatment in a naturalistic clinical setting.



Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: a double-blind controlled study.

Evidence is provided for the short-term efficacy of slow repetitive TMS in patients with recurrent major depression as compared with electroconvulsive therapy as well as the long-term outcome of this treatment in major depression and possibly other psychiatric disorders.

Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial.

Treatment with LFR-TMS may prove to be an appropriate initial repetitive TMS strategy in depression taking into account safety, tolerability, and efficacy considerations.

Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression.

Repetitive transcranial magnetic stimulation did not provide significantly greater improvement than did sham treatment and a 4-week course of rTMS, as administered in this study, was safe.

Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression: a systematic review and meta-analysis.

  • J. Couturier
  • Psychology, Medicine
    Journal of psychiatry & neuroscience : JPN
  • 2005
This meta-analysis suggests that rapid-rate rTMS is no different from sham treatment in major depression; however, the power within these studies to detect a difference was generally low.

Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial.

These placebo-controlled results suggest that daily left prefrontal repetitive transcranial magnetic stimulation has antidepressant activity when administered at these parameters.

Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression

Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.

Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis.

Transcranial magnetic stimulation (TMS) is a technology that allows for non-invasive modulation of the excitability and function of discrete brain cortical areas. TMS uses alternating magnetic fields