Efficacy and Safety of Pregabalin for the Treatment of Neuropathic Pain in Patients Undergoing Hemodialysis.

@article{Otsuki2017EfficacyAS,
  title={Efficacy and Safety of Pregabalin for the Treatment of Neuropathic Pain in Patients Undergoing Hemodialysis.},
  author={Tomoyasu Otsuki and Terumi Higuchi and Toshio Yamazaki and Erina Okawa and Kazuyoshi Okada and Masanori Abe},
  journal={Clinical drug investigation},
  year={2017},
  volume={37 1},
  pages={95-102}
}
OBJECTIVE Pregabalin is a gamma aminobutyric acid derivative administered for neuropathic pain. It binds to α2δ subunits of voltage-dependent calcium channels, and inhibits calcium inflow of synapses and the release of excitatory neurotransmitters. This study investigated the efficacy and safety of pregabalin in patients with peripheral neuropathic pain undergoing maintenance hemodialysis. METHODS This study was a prospective, open-label, single-arm, multi-center trial. Patients were treated… CONTINUE READING
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