Efficacy and Safety of Peginterferon Alfa-2a/Ribavirin in Methadone Maintenance Patients: Randomized Comparison of Direct Observed Therapy and Self-Administration

@article{Bonkovsky2008EfficacyAS,
  title={Efficacy and Safety of Peginterferon Alfa-2a/Ribavirin in Methadone Maintenance Patients: Randomized Comparison of Direct Observed Therapy and Self-Administration},
  author={Herbert L. Bonkovsky and Alan Douglas Tice and Rockford G Yapp and Jr Henry C Bodenheimer and Alexander Monto and Stephen J Rossi and Mark S Sulkowski},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={2757-2765}
}
BACKGROUND: Adherence to chronic hepatitis C (CHC) treatment may be particularly challenging in methadone maintenance patients. We assessed the safety, tolerability, and efficacy of peginterferon alfa-2a/ribavirin treatment in methadone maintenance patients previously untreated for CHC.METHODS: Patients were randomized 1:1 to direct observed therapy (DOT) or self-administration (SA) of peginterferon alfa-2a. DOT patients were seen weekly at methadone clinics; SA patients were seen less… CONTINUE READING

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