Efficacy and Safety of Ketamine in Patients with Complex Regional Pain Syndrome

@article{Azari2012EfficacyAS,
  title={Efficacy and Safety of Ketamine in Patients with Complex Regional Pain Syndrome},
  author={Pari Azari and David R. Lindsay and Dean Briones and Collin Clarke and Thomas Buchheit and Srinivas Pyati},
  journal={CNS Drugs},
  year={2012},
  volume={26},
  pages={215-228}
}
Despite being a recognized clinical entity for over 140 years, complex regional pain syndrome (CRPS) remains a difficult-to-treat condition. While there have been multiple therapies explored in the treatment of CRPS, NMDA antagonists such as ketamine continue to hold significant interest because of their potential ability to alter the central sensitization noted in chronic pain states. The objective of this review is to identify published literature for evidence of the efficacy and safety of… 
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TLDR
The available evidence does not support the use of calcitonin, vasodilators, or sympatholytic and neuromodulative intravenous regional blockade, and clear benefits have not been reported with stellate/lumbar sympathetic blocks, mannitol, gabapentin, and physical/occupational therapy.
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TLDR
Benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients is suggested, however, a randomized controlled trial will be necessary to prove its efficacy.
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TLDR
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