Efficacy and Safety of Dexmethylphenidate Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder

@article{Spencer2007EfficacyAS,
  title={Efficacy and Safety of Dexmethylphenidate Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder},
  author={Thomas J. Spencer and Lenard A Adler and James J. McGough and Rafael Muniz and Hai Jiang and Linda K Pestreich},
  journal={Biological Psychiatry},
  year={2007},
  volume={61},
  pages={1380-1387}
}

Long-Term Effectiveness and Safety of Dexmethylphenidate Extended-Release Capsules in Adult ADHD

Once-daily d-MPH-ER 20 to 40 mg is safe and effective for long-term treatment of adult ADHD.

Efficacy and safety of dexmethylphenidate extended-release capsules administered once daily to children with attention-deficit/hyperactivity disorder.

All three doses of d-MPH XR were significantly more effective than placebo in improving ADHD symptoms as confirmed by the teacher, parent and clinician and demonstrated a consistent safety profile.

Efficacy and Safety of SHP465 Mixed Amphetamine Salts in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Randomized, Double-Blind, Placebo-Controlled, Forced-Dose Clinical Study

Evaluating the efficacy and safety of SHP465 mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder (ADHD) found that the percentage of participants categorized as improved on Clinical Global Impressions-Improvement was higher with both SHP 465 MAS doses than with placebo (both nominal p < 0.001).

Prediction of placebo response in 2 clinical trials of lisdexamfetamine dimesylate for the treatment of ADHD.

It is found little evidence that demographic factors, prior pharmacotherapy, the emergence of adverse events during the trial, or changes in ADHD symptoms from the screening to baseline assessments predicted placebo response.

Relationship of ADHD Symptoms and Global Illness Severity in Adults Treated with Lisdexamfetamine Dimesylate

Although ADHD symptom scores demonstrate a linear relationship with global illness severity, the variance suggests that other factors not captured by symptom scales are also important in assessing patient outcomes in clinical practice.

A randomised, placebo-controlled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorder

MPH ER treatment in low to moderate doses was effective and safe in the treatment of ADHD in adults and the interpretation of the results is limited by the low dose-range used in this study, the high drop-out rate and placebo-response which might have affected the therapeutic effect size.

Efficacy and Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Dose-Escalation Study

In a dose escalation ranging from 36 to 108 mg/d, OROS methylphenidate is effective and well tolerated in the management of ADHD in adults.

Twenty-four-week treatment with extended release methylphenidate improves emotional symptoms in adult ADHD

  • M. RöslerW. Retz R. Ammer
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2010
MPH-ER was statistically superior to placebo in reducing emotional symptoms as assessed by the EDS and the ELS and also obsessive-compulsive symptoms and problems with self-concept were affected positively.

Clinical Effects of Lisdexamfetamine and Mixed Amphetamine Salts Immediate Release in Adult ADHD: Results of a Crossover Design Clinical Trial

In this crossover study, both LDX and MAS-IR had significant effects on ADHD clinician ratings and measures of executive function (with response rates of about 80%); patients in this monitored clinical trial were adherent with once dailyLDX and 3 times a dayMAS-IR, which may not be the case in real-world clinical practice.
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