Efficacy and Safety of α-Lipoic Acid Supplementation in the Treatment of Symptomatic Diabetic Neuropathy

@article{Foster2007EfficacyAS,
  title={Efficacy and Safety of $\alpha$-Lipoic Acid Supplementation in the Treatment of Symptomatic Diabetic Neuropathy},
  author={Tricia Stewart Foster},
  journal={The Diabetes Educator},
  year={2007},
  volume={33},
  pages={111 - 117}
}
  • T. Foster
  • Published 2007
  • Medicine
  • The Diabetes Educator
PURPOSE The purpose of this article is to review current evidence available for alpha-lipoic acid (ALA) and its ability to improve symptoms of peripheral diabetic neuropathy (PDN). METHODS This article searched MEDLINE from 1966 to November 2005 to identify clinical trials that supplemented ALA to individuals with type 1 or type 2 diabetes and positive sensory symptoms of PDN. Clinical trials to be included in this review met specific criteria of randomization, double masking, and placebo… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid
TLDR
It is substantiated that intravenous treatment with α-lipoic acid using a dose of 600 mg/day over 3 weeks is superior to placebo in reducing symptoms of diabetic peripheral neuropathy, without causing significant adverse reactions. Expand
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.
TLDR
A pivotal long-term multicenter trial of oral treatment with thioctic acid is being conducted in North America and Europe aimed at slowing the progression of diabetic polyneuropathy using a clinically meaningful and reliable primary outcome measure that combines clinical and neurophysiological assessment. Expand
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
TLDR
It is concluded that in a subgroup of patients after exclusion of patients with excessive test variability throughout the trial, TA appeared to have a beneficial effect on several attributes of nerve conduction. Expand
The Sensory Symptoms of Diabetic Polyneuropathy Are Improved With α-Lipoic Acid
TLDR
Intravenous racemic ALA, a potent antioxidant, rapidly and to a significant and meaningful degree, improved such positive neuropathic sensory symptoms as pain and several other neuropathic end points and appears to be a useful ancillary treatment for the symptoms of diabetic polyneuropathy. Expand
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.
TLDR
Findings indicate that a 3-week intravenous treatment with alpha-lipoic acid, followed by a 6-month oral treatment, had no effect on neuropathic symptoms distinguishable from placebo to a clinically meaningful degree, possibly due to increasing intercenter variability in symptom scoring during the study. Expand
Double‐blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy
TLDR
The results of this placebo-controlled trial showed that tramadol was effective and safe in treating the pain of diabetic neuropathy and no statistically significant treatment effects on sleep were identified. Expand
Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial.
TLDR
Gabapentin monotherapy appears to be efficacious for the treatment of pain and sleep interference associated with diabetic peripheral neuropathy and exhibits positive effects on mood and quality of life. Expand
Mexiletine in the Symptomatic Treatment of Diabetic Peripheral Neuropathy
TLDR
Because of conflicting reports of mexiletine's efficacy in the treatment of symptomatic DPN, this drug should be reserved for patients unresponsive or intolerant to standard therapy, without evidence of heart disease, and with sensations of burning, heat, formication, or stabbing pain. Expand
Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review.
TLDR
Antidepressants and anticonvulsants had the same efficacy and incidence of minor adverse effects in these tzoo neuropathic pain conditions, and there was no evidence that selective serotonin reuptake inhibitors (SSRIs) were better than older antidepressants, andno evidence that gabapentin was better than Older anticonVulsants. Expand
A systematic review of antidepressants in neuropathic pain
TLDR
Antidepressants are effective in relieving neuropathic pain and it is still unclear which drug class should be first choice, with very similar results for anticonvulsants. Expand
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