Efficacy and Dose-Dependent Safety of Intra-Arterial Delivery of Mesenchymal Stem Cells in a Rodent Stroke Model

@inproceedings{Yavagal2014EfficacyAD,
  title={Efficacy and Dose-Dependent Safety of Intra-Arterial Delivery of Mesenchymal Stem Cells in a Rodent Stroke Model},
  author={D R Yavagal and Baowan Lin and Ami P. Raval and Philip S. Garza and C Dong and Weizhao Zhao and {\'E}rika Bevilaqua Rangel and I K Mcniece and Tatjana Rundek and Ralph L. Sacco and Miguel A. P{\'e}rez-Pinz{\'o}n and Joshua M Hare},
  booktitle={PloS one},
  year={2014}
}
Intra-arterial (IA) delivery of mesenchymal stem cells (MSCs) for acute ischemic stroke is attractive for clinical translation. However, studies using rat model of stroke have demonstrated that IA MSCs delivery can decrease middle cerebral artery (MCA) flow, which may limit its clinical translation. The goal of this study is to identify a dose of IA MSCs (maximum tolerated dose; MTD) that does not compromise MCA flow and evaluate its efficacy and optimal timing in a rat model of reversible… CONTINUE READING
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