Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study.

@article{Wheeler2016EfficacySA,
  title={Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study.},
  author={Cosette Marie Wheeler and S. Rachel Skinner and Maria Rowena Del Rosario-Raymundo and Suzanne Marie Garland and Archana Chatterjee and Eduardo Lazcano-Ponce and J. Navarro Salmer{\'o}n and Shelly A. McNeil and Jack T. Stapleton and C{\'e}line Bouchard and Mark G. Martens and Deborah M Money and Swee Chong Quek and Barbara Romanowski and Carlos S. Vallejos and Bram ter Harmsel and Vera N. Prilepskaya and Kah Leng Fong and Henry Charles Kitchener and Galina Minkina and Yong Kuei Timothy Lim and Tanya Stoney and Nahida A Chakhtoura and Margaret E. Cruickshank and Alevtina Savicheva and Daniel Pereira da Silva and Murdo Ferguson and Anco C Molijn and Wim G. V. Quint and Karin Hardt and Dominique J Descamps and Pemmaraju Venkata Suryakiran and Naveen Karkada and Brecht Geeraerts and Gary O. Dubin and Frank Struyf},
  journal={The Lancet. Infectious diseases},
  year={2016},
  volume={16 10},
  pages={
          1154-1168
        }
}
BACKGROUND Although the risk of human papillomavirus (HPV) infection is greatest in young women, women older than 25 years remain at risk. We present data from the VIVIANE study of the HPV 16/18 AS04-adjuvanted vaccine in adult women after 7 years of follow-up. METHODS In this phase 3, double-blind, randomised controlled trial, healthy women older than 25 years were enrolled (age stratified: 26-35 years, 36-45 years, and ≥46 years). Up to 15% in each age stratum had a history of HPV infection… CONTINUE READING
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