Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model.

@article{Hamouda2010EfficacyIA,
  title={Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model.},
  author={Tarek Hamouda and Alexander Chepurnov and N J Mank and Jessica Knowlton and Tatiana S Chepurnova and Andrzej Myc and Joyce Sutcliffe and James R Baker},
  journal={Human vaccines},
  year={2010},
  volume={6 7},
  pages={585-94}
}
Mutations of influenza virus increase concerns of worldwide epidemics resulting from the newly emergent strains. Current influenza vaccines are inefficient and require annual vaccinations. W805EC adjuvant is an oil-in-water emulsion composed of nanodroplets with an average diameter of approximately 400 nm. The nanoemulsion adjuvant has been used successfully to stimulate the immune response when mixed with several other antigens in animal models. In this study, W805EC nanoemulsion adjuvant… CONTINUE READING