Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus

  title={Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus},
  author={K. Srivastava and S. Bhartiya and Vrushabh Gavli and R. Patil and S. Rajadhyaksha},
  journal={Indian Pediatrics},
Objective To evaluate the efficacy and tolerability of intravenous fosphenytoin in children with status epilepticus, and resulting serum total phenytoin levels. Methods In this prospective study, 51 children aged less than 18 years received intravenous loading dose of fosphenytoin (18-20 mg/kg). Serum total phenytoin levels were estimated at 90 -100 minutes. Outcomes studied were ( i ) seizure control and local and/ or systemic adverse effects in next 24 hours and ( ii ) phenytoin levels and… Expand

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