Effervescent redispersion of lyophilized polymeric nanoparticles.

  title={Effervescent redispersion of lyophilized polymeric nanoparticles.},
  author={Carlos E Figueroa and Douglas H. Adamson and Robert K. Prud'homme},
  journal={Therapeutic delivery},
  volume={4 2},
BACKGROUND Freeze-drying is an attractive method for converting nanoparticulate pharmaceutical dispersions into a stable form with a long shelf life. However, practical challenges in translating laboratory practice to the clinic, such as high protectant osmolarity and infeasible reconstitution methods, currently limit lyophilized formulation development of nanoparticle therapeutics. RESULTS We demonstrate the use of effervescent redispersion for the reconstitution of lyophilized polymeric… CONTINUE READING