• Biology
  • Published 1985

Effectsof Calmodulin Antagonists andCytochalasins onProliferation and Differentiation of HumanPromyelocytic LeukemiaCellLineHL-601

@inproceedings{Matsui1985EffectsofCA,
  title={Effectsof Calmodulin Antagonists andCytochalasins onProliferation and Differentiation of HumanPromyelocytic LeukemiaCellLineHL-601},
  author={Toshimitsu Matsui and Yoshinobu Nakao and Nobuhisa Kobayashi and Tamio Koizumi and Toshitaro Nakagawa and Michizo Kishihara and Takuo Fujita},
  year={1985}
}
To identify the possible roles of Ca2+-relatedproteins, calmodulin and microfilaments in leukemic cells, we tested the effect of calmodulin antagonists and cytochalasins on proliferation and differentiation of human promyelocytic leukemic HL-60 cells. The growth of HL-60 was inhibited by A/-(6-aminohexyl)-5-chloro-1naphthalenesulfonamide, A/-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide, and trifluoperazine dihydrochloride. In contrast, the 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-induced… CONTINUE READING