Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

@article{Bloom2013EffectsUI,
  title={Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.},
  author={A. Joseph Bloom and Sharon E Murphy and Maribel Mart{\'i}nez and Linda B. von Weymarn and Laura J. Bierut and Alison M. Goate},
  journal={Pharmacogenetics and genomics},
  year={2013},
  volume={23 2},
  pages={62-8}
}
BACKGROUND Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom-containing drugs and xenobiotics, including nicotine. Rare mutations in FMO3 are responsible for defective N-oxidation of dietary trimethylamine leading to trimethylaminuria, and common genetic variation in FMO3 has been linked to interindividual variability in metabolic function that may be substrate specific. METHODS A genetic model of CYP2A6 function is used as a covariate to reveal… CONTINUE READING
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