Effects related to indomethacin prolonged survival and decreased tumor-growth in a mouse-tumor model with cytokine dependent cancer cachexia.

@article{Lonnroth1995EffectsRT,
  title={Effects related to indomethacin prolonged survival and decreased tumor-growth in a mouse-tumor model with cytokine dependent cancer cachexia.},
  author={C Lonnroth and G{\"o}sta Svaninger and Johan Gelin and Christian Cahlin and B Iresjo and E. Cvetkovska and S. Edstrom and Marianne Andersson and Elisabeth Svanberg and Kent G Lundholm},
  journal={International journal of oncology},
  year={1995},
  volume={7 6},
  pages={1405-13}
}
Tumor-bearing mice with two different locally growing malignant tumors (epithelial like, MCG 101; malignant melanoma, K1735-M2) were used to evaluate the putative role of prostaglandins for survival and local tumor growth in experimental cancer. Daily systemic injections of indomethacin (1 mu g/g bw) were used to block prostaglandin production in normal and T-cell deficient tumor-bearing nude mice. Tumor progression was determined by measurements of tumor weight, DNA-synthesis, cell cycle… CONTINUE READING

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