Effects on the immune response of rats rendered leukopenic with 4-(p-chlorophenylthio)-butanol (W-2719) and its major metabolites.

Abstract

4-(p-Chlorophenylthio)butanol (W-2719) and its major acid metabolites W-2718 (butyrate) and W-2683 (acetate), when administered as drug-diet admixtures to male and female Sprague-Dawley rats for five weeks (approximately 200.0 mg/kg/day), induced a marked leukopenia. Effect on the primary and secondary immune responses to bovine serum albumin (BSA) immunization was that of suppression as evidenced by strikingly reduced passive hemagglutination serum titers.

Cite this paper

@article{Sofia1979EffectsOT, title={Effects on the immune response of rats rendered leukopenic with 4-(p-chlorophenylthio)-butanol (W-2719) and its major metabolites.}, author={R. Duane Sofia and G M Fukui and Brian J Ludwig}, journal={Arzneimittel-Forschung}, year={1979}, volume={29 12}, pages={1868-70} }