Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein.

@article{Kraschnefski2009EffectsOS,
  title={Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein.},
  author={Mark J. Kraschnefski and Andrea Bugarcic and Fiona E. Fleming and Xing Yu and Mark von Itzstein and Barbara S Coulson and Helen Blanchard},
  journal={Glycobiology},
  year={2009},
  volume={19 3},
  pages={
          194-200
        }
}
The rotavirus spike protein VP4 mediates attachment to host cells and subsequent membrane penetration. The VP8(*) domain of VP4 forms the spike tips and is proposed to recognize host-cell surface glycans. For sialidase-sensitive rotaviruses such as rhesus (RRV), this recognition involves terminal sialic acids. We show here that the RRV VP8(*)(64-224) protein competes with RRV infection of host cells, demonstrating its relevance to infection. In addition, we observe that the amino acids revealed… CONTINUE READING

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