Effects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine.

@article{Tao2002EffectsOS,
  title={Effects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine.},
  author={Rui Tao and Anne Fray and Sue Aspley and Richard Brammer and David J. Heal and Sidney B. Auerbach},
  journal={European journal of pharmacology},
  year={2002},
  volume={445 1-2},
  pages={69-81}
}
Hypothalamic 5-HT (serotonin) regulates food intake, energy expenditure and bodyweight. Using in vivo microdialysis, we determined the effects of various anorectic drugs on hypothalamic extracellular 5-HT levels during the dark phase when rats predominantly feed. Phentermine and aminorex, which were originally considered to be catecholaminergic drugs, markedly increased 5-HT efflux in rat hypothalamus. Their actions were less profound than D-fenfluramine, but considerably greater than that of… CONTINUE READING

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