Effects on rabbit nodal, atrial, ventricular and Purkinje cell potentials of a new antiarrhythmic drug, cibenzoline, which protects against action potential shortening in hypoxia.

@article{Millar1982EffectsOR,
  title={Effects on rabbit nodal, atrial, ventricular and Purkinje cell potentials of a new antiarrhythmic drug, cibenzoline, which protects against action potential shortening in hypoxia.},
  author={John S Millar and E M Vaughan Williams},
  journal={British journal of pharmacology},
  year={1982},
  volume={75 3},
  pages={469-78}
}
1 The effects of cibenzoline (UP 339-01), a new anti-arrhythmic drug, have been investigated in various cardiac tissues. 2 UP 339-01 produced a bradycardia, due partly to prolongation of the intracellularly recorded sinus node action potential duration (APD) and partly to depression of the maximum rate of depolarization (MRD). The slope of the slow diastolic depolarization was not significantly reduced. 3 UP 339-01 was not a beta-adrenoceptor antagonist. 4 UP 339-01 was negatively inotropic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

The utility of the small rodent electrocardiogram in toxicology.

Toxicological sciences : an official journal of the Society of Toxicology • 2011

Similar Papers

Loading similar papers…