Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.

@article{Dahl2007EffectsOP,
  title={Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.},
  author={G{\"o}ran Dahl and Anja Sandstr{\"o}m and Eva {\AA}kerblom and U Helena Danielson},
  journal={The FEBS journal},
  year={2007},
  volume={274 22},
  pages={5979-86}
}
This study of the full-length bifunctional nonstructural protein 3 from hepatitis C virus (HCV) has revealed that residues in the helicase domain affect the inhibition of the protease. Two residues (Q526 and H528), apparently located in the interface between the S2 and S4 binding pockets of the substrate binding site of the protease, were selected for… CONTINUE READING