Effects on offspring of chronic maternal methamphetamine exposure.

  title={Effects on offspring of chronic maternal methamphetamine exposure.},
  author={Joan C. Martin},
  journal={Developmental psychobiology},
  volume={8 5},
Twenty-five Sprague-Dawley derived rats were administered 1.0, 3.0 or 5.0 mg/kg of methamphetamine HC1 or saline twice daily throughout gestation beginning on Day 1 of pregnancy. Rats were allowed to deliver normally; offspring were culled to 8 and sexed on Day 7, and weaned on Day 21. All females had viable litters except at the 5.0 mg/kg dose where 4 of 7 failed to deliver. The rats given methamphetamine delivered earlier than did controls. Weight gain over gestation decreased as a function… CONTINUE READING

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