Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B

@article{Smart1999EffectsON,
  title={Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B},
  author={Philip Smart and E. Birgitte Lane and D. P. Lane and Carol A Midgley and Borivoj Vojtesek and Sonia Lain},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={7378-7386}
}
p53 tumour suppressor protein levels and p53-dependent transcriptional activity have been recently shown to increase in cells treated with leptomycin B (LMB), an inhibitor of nuclear export. Experiments presented here show that LMB treatment leads to growth arrest and a senescence-like phenotype in human normal fibroblast cultures. This effect is reversible after removal of the drug and further passage by trypsinization. Instead, LMB has a strong cytotoxic effect on human neuroblastoma cell… CONTINUE READING

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