Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain

@article{KlingPetersen2005EffectsOL,
  title={Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain},
  author={Torben Kling-Petersen and Elisabeth Ljung and Kjell A. Svensson},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={102},
  pages={209-220}
}
Compounds showing an in vitro binding preference for the dopamine D3 vs. D2 receptors were tested for effects on locomotor activity after local application in the nucleus accumbens (N Acc) and the ventral tegmental area (VTA) of the rat brain. R-(+)-7-OH-DPAT, a dopamine D3 preferring agonist, inhibited spontaneous locomotor activity over a wide dose range after injection into the N Acc. A decrease in activity over a wide dose range was also seen after local application into the VTA of both R… 
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Both (+)-UH232 and raclopride produced a dose dependent decrease in spontaneous locomotor activity when examined as the total activity count over 60 minutes after local application into the N Acc.
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