Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats.

@article{Bennetzen2008EffectsOF,
  title={Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats.},
  author={Marianne Faurholt Bennetzen and Maria P Nielsen and Bj\orn Richelsen and Steen B\onl\okke Pedersen},
  journal={Obesity},
  year={2008},
  volume={16 11},
  pages={2451-5}
}
Endocannabinoids act through the cannabinoid receptor 1 (CB1) and has both orexigenic and peripheral metabolic effects. It is not yet fully understood whether all the beneficial effects on the metabolic profile by CB1 antagonism are induced by the weight loss or also by direct peripheral effects. The present study was intended to further elucidate this question and to investigate whether tolerance development to the hypophagic effect could be attenuated by cyclic treatment. We performed an… CONTINUE READING