Effects on digestive secretions.

@article{Young2005EffectsOD,
  title={Effects on digestive secretions.},
  author={Andrew Young},
  journal={Advances in pharmacology},
  year={2005},
  volume={52},
  pages={
          123-50
        }
}
Rat amylin subcutaneously injected into rats dose-dependently inhibits pentagastrin-stimulated gastric acid secretion and protects the stomach from ethanol-induced gastritis. The ED50s for these actions (0.050 and 0.036 microg, respectively) are the lowest for any dose-dependent effect of amylin thus far described, and their similar potencies are consistent with a mechanistic (causal) association. At higher amylin doses, inhibition of gastric acid secretion was almost complete (93.4%). Gastric… CONTINUE READING