Effects on aggregation of human platelets of two xanthines and their interactions with adenosine.

@article{Vinge1984EffectsOA,
  title={Effects on aggregation of human platelets of two xanthines and their interactions with adenosine.},
  author={E. Vinge and K. Andersson and C. Persson},
  journal={Acta physiologica Scandinavica},
  year={1984},
  volume={120 1},
  pages={
          117-21
        }
}
  • E. Vinge, K. Andersson, C. Persson
  • Published 1984
  • Chemistry, Medicine
  • Acta physiologica Scandinavica
  • Adenosine receptor antagonism has been suggested to be the cellular basis for many extrapulmonary actions of xanthine derivatives, such as theophylline. Enprofylline (3-propylxanthine) is a poor adenosine antagonist but is five times as potent as theophylline as a bronchodilator in man. Adenosine is a potent inhibitor of platelet aggregation, but also xanthines are considered to exert this action. In the present study, effects of theophylline and enprofylline on ADP-induced aggregation of human… CONTINUE READING
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